What are the synergies between Ketones and Caffeine?

Updated by Chrissy Rojas

For years our community has been taking their Ketone-IQ around their morning coffee and stacked with caffeine as a pre-workout, and we hear all day every day that the combo of Ketone-IQ and Caffeine feels, well, fantastic.

And we agree! Ketone-IQ + Caffeine wraps up all the benefits of both Ketones and Caffeine into a single package for fast-acting, long-lasting energy.

Key Takeaways:


The combination of ketones and caffeine can enhance both physical and cognitive performance, making it beneficial for athletes and individuals, especially those with high cognitive demands. Studies have shown that caffeine can improve endurance and strength performance, while ketones provide an efficient energy source that can sustain physical activities for longer periods (1,2,4,5)

Brain Function

Ketones provide an alternative and efficient energy source for the brain, especially during low glucose states. This has been shown to improve cognitive function and provide neuroprotective effects (3). Caffeine, on the other hand, enhances alertness and cognitive function by blocking adenosine receptors and stimulating the central nervous system (4).


The dual supplementation offers a complementary approach, with caffeine offering immediate cognitive and performance boosts, and ketones providing sustained energy and neuroprotection. The combination can help reduce perceived exertion and fatigue during physical activities, making it a potent ergogenic aid (5)

By combining these powerful elements, Ketone-IQ + Caffeine delivers a balanced, effective energy boost that can help support both mental and physical performance.


  1. Cox, P. J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, A. J., Stubbs, B., West, J., McLure, S. W., King, M. T., Dodd, M. S., Holloway, C., Neubauer, S., Drawer, S., Veech, R. L., Griffin, J. L., & Clarke, K. (2016). Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell metabolism, 24(2), 256–268. https://doi.org/10.1016/j.cmet.2016.07.010
  2. Ganio, M. S., Klau, J. F., Casa, D. J., Armstrong, L. E., & Maresh, C. M. (2009). Effect of caffeine on sport-specific endurance performance: a systematic review. Journal of strength and conditioning research, 23(1), 315–324. https://doi.org/10.1519/JSC.0b013e31818b979a
  3. Omori NE, Woo GH, Mansor LS. Exogenous Ketones and Lactate as a Potential Therapeutic Intervention for Brain Injury and Neurodegenerative Conditions. Front Hum Neurosci. 2022 Apr 28;16:846183. https://pubmed.ncbi.nlm.nih.gov/36267349/
  4. McLellan, T. M., Caldwell, J. A. , Lieberman, H. R. (2016). A review of caffeine’s effects on cognitive, physical and occupational performance. Neuroscience & Biobehavioral Reviews Volume 71, 294-312. https://www.sciencedirect.com/science/article/pii/S0149763416300690?via%3Dihub
  5. Jodra, P., Lago-Rodríguez, A., Sánchez-Oliver, A.J. et al. Effects of caffeine supplementation on physical performance and mood dimensions in elite and trained-recreational athletes. J Int Soc Sports Nutr 17, 2 (2020). https://doi.org/10.1186/s12970-019-0332-5

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